a-MSH and its receptors in regulation of tumor necrosis factor-a production by human monocyte/macrophages
نویسندگان
چکیده
S. TAHERZADEH,1 S. SHARMA,1 V. CHHAJLANI,2 I. GANTZ,3 N. RAJORA,1 M. T. DEMITRI,4 L. KELLY,1 H. ZHAO,1 T. ICHIYAMA,1 A. CATANIA,4 AND J. M. LIPTON1,5 Departments of 1Physiology and 5Anesthesiology and Pain Management, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235-9040; 2Astra Hassle, 431 83 Molndal, Sweden; 3Department of Surgery, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0682; and 4Third Division of Internal Medicine, IRCCS Ospedale Maggiore, Milan, Italy 20122
منابع مشابه
α-MSH and its receptors in regulation of tumor necrosis factor-α production by human monocyte/macrophages.
The hypothesis that macrophages contain an autocrine circuit based on melanocortin [ACTH and α-melanocyte-stimulating hormone (α-MSH)] peptides has major implications for neuroimmunomodulation research and inflammation therapy. To test this hypothesis, cells of the THP-1 human monocyte/macrophage line were stimulated with lipopolysaccharide (LPS) in the presence and absence of α-MSH. The inflam...
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